Neoantigens have been characterized as promising therapeutic targets for cancer immunotherapy because they are newly expressed peripherally on cancer tissue and, thus, are not subject to thymic ...

The research team engineered CD8+ Jurkat T cells to express SVAR16, a human TCR with intermediate-to-high 2D affinity for the SARS-CoV-2-derived epitope HLAA2:01–YLQ, using lentiviral transduction.

The interaction between a class I peptide-major histocompatibility complex (pMHC) and a T cell receptor (TCR) plays a central role in the elicitation of CD8 + T cell immune responses. As a result, ...